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Description - Co-trimoxazole AHFS Monographs AHFS Monographs

Treatment of acute otitis media (AOM) in adults† and children caused by susceptible Streptococcus pneumoniae or Haemophilus influenzae186 272 273 274 278 a when the clinician makes the judgment that the drug offers some advantage over use of a single anti-infective.a 186 Not a drug of first choice; considered an alternative for treatment of AOM, especially for those with type I penicillin hypersensitivity.321 Because amoxicillin-resistant S. pneumoniae frequently are resistant to co-trimoxazole, the drug may not be effective in patients with AOM who fail to respond to amoxicillin.302 321 Data are limited regarding safety of repeated use of co-trimoxazole in pediatric patients 186 a